Volume 2, Issue 7
Cytokine Levels in Patient with Chronic Heart Failure
Author: Galyna Kuryliv 1*
1. Department of Internal Medicine #2, Ivano-Frankivsk National Medical University, 76008, 2 Halytska str., Ivano-Frankivsk, Ukraine.
Abstract: Plasma concentrations of cytokins TGF-β1, IL-10, TNF-α in patient with heart failure on the basis of coronary heart disease and myocardial infarction according to the type of left ventricular dysfunction were studied. The aim of research was to improve treatment of chronic heart failure patients by regulating the levels of cytokins by adding to basic therapy medicines Imunofan and Metamax. It was found the increased levels of TGF-β1, TNF-α, IL-10 in all patients. The level of TGF-β1 in patients with preserved left ventricular ejection fraction and systolic dysfunction of the left ventricle increased after treatment. We found the increased level of IL-10 in patients. After treatment a clear decrease of IL-10 is typical for patients with preserved ejection fraction of left ventricular, whereas in patients with systolic dysfunction of left ventricular IL-10 levels remain more constant. Observed increasing of TNF-α, which decreased after treatment in all groups, but most definitely in patients with preserved ejection fraction of left ventricular.
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Table 1: The influence of basic therapy, basic therapy+ Imunofan, basic therapy+Metamax, basic therapy+Imunofan+Metamax on the levels of cytokins in the patiens with preserved ejection fraction of left ventricle (М±m).
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