Volume 2, Issue 5
Preclinical evaluation of antidepressant activity of Boswellia serrata by Tail Suspension Test
Author: Prabhakar Adake*, Chandrashekar R , S.N Rao
Assistant Professor, Department of Pharmacology, Yenepoya Medical College, Yenepoya University, Mangalore-575018, Karnataka, India.
Abstract: The objective of present study is to evaluate the antidepressant activity of Boswellia serrata and compare with imipramine in Swiss albino mice by Tail Suspension Test. A total of 30(n=30) Swiss albino male mice were used in the present study. They were divided into five groups of six mice in each. Control group received normal saline 10mg/kg, imipramine 10mg/kg for standard and test groups received Boswellia serrata in three different doses 50/kg, 100mg/kg and 200/kg per orally. They were evaluated for antidepressant activity by Tail Suspension Test (TST), after 60 minutes of drug administration. Duration of immobility was noted for six minutes for each mouse in all groups. Results were analyzed by ANOVA followed by Dunnet’s multiple comparison test. Boswellia serrata at the dose of 100 mg/kg significantly reduced the immobility time in Tail Suspension Test model (TST) compared to the control group (p < 0.001). Present study shown Boswellia serrata has significant antidepressant activity at the dose of 100mg/kg in acute models of depression.
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