Volume 2, Issue 4
Formulation and Evaluation of Ciprofloxacin Microspheres for Nasal Drug Delivery
Author: S. Duraivel*, Harish.G, B. Pragati Kumar, Debjit Bhowmik, Sunil Midimalapu
Nimra College of Pharmacy, Ibrahimpatnam, Vijayawada, Andhra Pradesh, India.
Abstract: The aim of the study was to evaluate ciprofloxacin-hydrochloride loaded microspheres using copolymers synthesized from acrylic and methacrylic acid esters as a the retardant material for nasal administration.. Microspheres prepared by emulsion solvent diffusion method using an acetone and dichloro methane system. Formulation parameters and processing parameters like ratio of drug to polymer (1:1, 1:1.5, 1:2 and 1:3) concentration of aerosol, volume of water and stirring speed were optimized. Aerosil was used as the inert dispersing carrier to increase the dissolution rate. The prepared microspheres characterized for their micromeritic propertics and drug loading, as well as Differential scanning calorimetry and scanning electron microscopy. The In vitro release studies performed in Phosphate buffer pH 7.4. The prepared microspheres should white, free flowing and spherical in shape. The drug-loaded microspheres showed 86-96% of entrapment and release contected up to 8-10 hr.
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