Volume 2, Issue 2
Recent Trends in Penetration Enhancer Used in Transdermal Drug Delivery System
Authors: Debjit Bhowmik*, Vazram Dasari, S.Duraivel, K.P.Sampath Kumar.
Karpagam university, coimbatore Tamil Nadu, India.
Abstract: The TDDS are defined as self-contained, discrete dosage forms which, when applied to the intact skin, deliver the drug(s), through the skin, at a controlled rate to the systemic circulation.Transdermal drug delivery is a viable administration route for potent, low-molecular weight therapeutic agents which cannot withstand the hostile environment of gastrointestinal tract and/or subject to considerable first-pass metabolism by the liver. Studies have been carried out to find safe and suitable permeation enhancers to promote the percutaneous absorption of a number of drugs. Skin permeation enhancement technology is a rapidly developing field which would significantly increase the number of drugs suitable for Transdermal drug delivery, with the result that skin will become one of the major routes of drug administration in the next decade. Research in this area has proved the usefulness of physical and chemical penetration enhancers in the enhancement of drug permeation through skin. The physical and chemical penetration enhancement methods discussed in this review are promising. Focus should be on skin irritation, with a view to selecting penetration enhancers which possess optimum enhancement effects with minimal skin irritation. The Transdermal route now ranks with oral treatment as the most successful innovative research area in drug delivery, with around 40% of the drug delivery candidate products under clinical evaluation related to Transdermal or dermal system.
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