Volume 2, Issue 11
The influence of Matrix Metalloproteinase-9 upon the course of psoriasis in patients suffering from liver affections
Author: N.G.Virstyuk, M.S.Voloschynovych
Abstract: The aim of our research has been the study of changes in the MMP-9 content in the blood of the patients suffering from psoriasis taking into account liver affection.
Materials and Methods: It has been examined 128 patients suffering from uncomplicated plaque-like psoriasis of moderate degree of severity. Liver functional state has been evaluated according to the results of ultrasound and biochemical investigations. MMP-9 content in blood serum of the patients has been assessed by means of immunoferment analysis.
Results: The increase of MMP-9 in the blood of patients was detected. The effect of MMP-9 for psoriasis in the direct correlation between these indices and index PASI was showed. (r = +0.43; p<0.05)
Conclusion: The relation between MMP-9 in the blood of patients with psoriasis of moderate severity with disorder of the functional liver state was ascertained, that indicating for their combined participation in the immunopathogenesis of comorbid disorders.
Blood MMP-9 level in patients suffering from psoriasis depending on liver affection, ng/ml
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