Volume 1, Issue 9
Formulation And Evaluation Of Sumatriptan Succinate Oral Disintegrating Tablets and Comparision of Disintegrating Property Between Superdisintegrants And Simpledisintegrants
Author: Rapolu Bharath Kumar.
Abstract: The main objective of this research work was to formulate and evaluate the oral disintegrating tablets of sumatrptan succinate of dose 25 mg an anti-migraine drug. The tablets are prepared by direct compression method. The formulations was optimized by incorporating varying composition of Microcrystalline cellulose (Avicel PH 102), mannitol as diluent, crospovidone, croscaramellose and sodium starch glycollate as superdisintegrants, Other exipients like Carbomer (carbopol 940), Sodium CMC and Sodium Alginate were used, which acts as disintegrants when used at various concentrations, magnesium stearate as lubricant, talc as glidant. All the excipients are tested for compatability with model drug, which revealed that there was no physical and chemical interaction occurred. The preformulation parameters such as bulk density, tapped density, compressibility index and hausner ratio were analyzed for prepared tablet blend before compression. The thickness, hardness, friability, weight variation, disintegration time and drug content uniformity was evaluated for core tablets. The effect of these variables on drug release also studied. The In-Vitro drug release studied were Performed in the USP dissolution apparatus-II (paddle type) using phosphate buffer of pH 6.8 as dissolution media at 50 rpm speed and temperature of 37±5 °C. the sampling was done at periodic time intervals of 2, 4, 6, 8 and 10 minutes and was replaced by equal volume of dissolution media after each withdrawal. The cumulative amount of drug release at different intervals is estimated using UV-method. Based on the evaluation result F-3 trial formulation (containing 6% crospovidone) was selected as best formulation among superdisintegrants and F-10 trial (containing 2% carbopol 940p) was selected as best formulation among simpledisintegrants.
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