Volume 1, Issue 7
Preparation and evaluation of floating matrix tablets of Ranitidine Hydrochloride
Author: M. Ehsanul H. Chowdhury, M. S. I. Pathan
Abstract: The objective of this research was to prepare a gastroretentive drug delivery system of Ranitidine hydrochloride. Quick GI transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to decreased efficacy of the administered dose and thus less patient compliance. Floating matrix tablets containing 150 mg Ranitidine were developed using different effervescent salts and polymer in combinations. The tablets were prepared by direct compression method, using polymers such as Hydroxy propyl methyl cellulose, Psyllium husk and Carbopol 934 in combination. Sodium bicarbonate and citric acid was incorporated as a gas- generating agent. Different tablet properties, floating lag time and floating time, swelling index and in-vitro drug release for 12h in 0.1mol/l HCl at 37 ºC were studied. The result of floating lag time indicates that increased content of Sodium bicarbonate and Citric acid in the formulations causes decreased floating lag time. All the batches showed floating time more than 12 hours. It is also observed that formulation A7 containing highest combination of polymer shows better controlled release behavior.
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