Volume 1, Issue 11
SILK- BASED DRUG DELIVERY SYSTEMS
Author: B. Pragati Kumar*, S.Durai vel ,Harish.G, Debjit Bhowmik
Nimra College of Pharmacy, Ibrahimpatnam ,Vijayawada, Andhra Pradesh, India.
Abstract: Silks are biodegradable, biocompatible, self-assembling proteins that can also be tailored via genetic engineering to contain specific chemical features, offering utility for drug and gene delivery. Silkworm silk has been used in biomedical sutures for decades and has recently achieved Food and Drug Administration approval for expanded biomaterials device utility. With the diversity and control of size, structure and chemistry, modified or recombinant silk proteins can be designed and utilized in various biomedical application, such as for the delivery of bioactive molecules. Silk proteins have been used successfully in the biomedical field as sutures for decades, and also explored as biomaterials for cell culture and tissue engineering,achieving Food and Drug Administration approval for such expanded utility because of their excellent mechanical properties, versatility in processing and biocompatibility.This topic focuses on the biosynthesis and applications of silk- based multi-block copolymer systems and related silk protein drug delivery systems.
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