Volume 1, Issue 11
In vitro study on interaction of ketotifen fumerate with amoxicillin trihydrate at different pH and are confirmed by IR spectroscopy
Authors: Mohammed Aktar Sayeed, Mohammed Sahaban, Md. Khalequeuzzaman, Md. Rafikul Islam , Sohel Rana.
Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh.
Abstract: The purpose of the present study was to investigate interaction between ketotifen fumerate and amoxicillin trihydrate in aqueous media of various pH (1.2, 2.8, 6.8 and 7.4). By using Job’s continuous-variation analysis and Ardon’s spectrophotomeric measurement methods, the values of stability constants of amoxicillin with ketotifen were determined at a fixed temperature (37 °C) at each of the medium pH. Stability constant, ranging between 0.0011 and 57.43, were derived from Ardon’s plot, indicating that complexes formed, as a result of interaction between the drugs, were comparatively stable. However, when ketotifen is interacted with amoxicillin, stability constant were less than 1 at both gastric pH (1.2, 2.8) and intestinal pH (6.8 and 7.4) . But in vice versa when amoxicillin is interacted with ketotifen, stability constant values were more than 1 at gastric pH as well as at intestinal pH. Concurrent administration of ketotifen and amoxicillin trihydrate would result in the formation of a stable complex and this is likely to reduce the therapeutic activities of both drugs. There are many extra peaks observed in the IR spectra of interacted product of ketotifen fumarate with Amoxicillin trihydrate in the mixture ratio of 1:1 either in aqueous or chloroform extracts, in compared to that of their pure form.
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