Vol. 8, Issue 7 (2019)

Objective: The aim of the present study was to formulate and evaluate the aquatic ethanol extract of Kigelia africana fruits as efficient antibacterial therapy.

Methods: Topical formulations were prepared by incorporating the extract in two aqueous cream formulations and two emulgel formulations (1%, 2%, 3%, 5%, 7% and 10% w/w) and evaluated for organoleptic characteristics, melting point, pH, viscosity, spreadability, extrudability, microbial limit, in vitro activity, in vitro release, ex vivo diffusion and stability.

Results: The study showed that the formulated creams and emulgels had acceptable organoleptic properties, melting point, pH, viscosity, spreadability, extrudability and microbial limit. The in vitro activity, release rate and diffusion rate was higher in emulgels than creams. Among cream formulations one formula (10%) exhibited significant in vitro activity, release and diffusion rate while one emulgel formula (7% and 10%) provide significant in vitro activity, release and diffusion rate. The effective aqueous cream and one formula of emulgels exhibited stability while another emulgel showed physical instability.

Conclusion: The present study concludes that the formulated cream and emulgel were safe, effective and stable antibacterial formulations for the topical delivery of the aquatic ethanol extract of Kigelia africana fruits.