Vol. 8, Issue 6 (2019)
Formulation development and evaluation of fast disintegrating tablet of lornoxicam by using co-processed super disintegrants
Ashwani Kumar Suthar, Mohit Mehta, Harish Kumar Bishnoi, Anil Kumar and Beena Kumari
The concept of fast dissolving drug delivery system emerged from the desire to provide patient with more convenient means of taking their medication. It is difficult for many patients to swallow tablets and hard gelatin capsules. The main objective of the study is to develop reproducible formulation of fast dissolving tablets of Lornoxicam already used therapeutic molecule to enhance effectiveness, and to avoid side effects (gastric irritation) of the drug. Different batches of tablets were prepared by direct compression method using different concentration of superdisintegrants like Cross povidone, Cross carmellose sodium, Sodium starch glycollate. Superdisintegrants were used by three means i.e. by direct addition of superdisintegrants, by using physical mixture of superdisintegrants and by using co-processed mixture of superdisintegrants. In this study total four formulations were formulated by direct addition of superdisintegrants, eighteen formulations were formulated by addition of physical mixture of superdisintegrants in different ratios and eighteen formulations were formulated by addition of co-processed mixture of superdisintegrants in different ratios. Before compression preformulation studies were done which includes characterization of blend and physical compatibility studies with excipients. Effect of change in superdisintegrant and their concentration on the formulation was studied. Final batches were compared for superiority of superdisintegrants in the formulation of FDT of Lornoxicam.
How to cite this article:
Ashwani Kumar Suthar, Mohit Mehta, Harish Kumar Bishnoi, Anil Kumar and Beena Kumari. Formulation development and evaluation of fast disintegrating tablet of lornoxicam by using co-processed super disintegrants. The Pharma Innovation Journal. 2019; 8(6): 55-61.