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Vol. 8, Issue 6 (2019)

Stability indicating HPLC method for methocarbamol and diclofenac sodium in combined dosage form

Author(s):
Nikita Patel
Abstract:
High performance liquid chromatography is the most accurate method widely used for the quantitative as well as qualitative analysis of drug product and is used for determining drug product stability. Stability indicating HPLC method is used to separate various drug related impurities that are formed during the synthesis or manufacture of drug product. In this article, we will discuss the strategies and issues regarding the development of stability indicating HPLC system for drug substance. Many key chromatographic factors were evaluated in order to optimize the detection of all potentially relevant degradants. The method should be carefully examined for its ability to distinguish the primary drug components from its impurities. Newer chemical entities and drug products rely to undergo forced degradation studies which may be helpful in developing and demonstrating the specificity of such stability indicating methods. At every stage of drug development, practical recommendations are provided which will help to avoid failuresms.
Pages: 48-51  |  178 Views  9 Downloads
How to cite this article:
Nikita Patel. Stability indicating HPLC method for methocarbamol and diclofenac sodium in combined dosage form. The Pharma Innovation Journal. 2019; 8(6): 48-51.
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