Vol. 8, Issue 5 (2019)

Author(s):
BVP Deepthi, K Kartheswari, G Akhila, Hadia Huma, Uma Ruqiya Basharath and Dr. JVC Sharma

Abstract:
In the present study, an attempt was made to prepare buccal tablets of Ivabradine HCL (an anti-anginal drug), in order to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. Buccal tablets containing the drug were prepared by direct compression method using combinations of polymers (such as sodium CMC, HPMC K200M and karaya gum). Estimation of Ivabradine HCL was carried out spectrophotometrically at 292 nm. The Buccal tablets were evaluated for various physical and biological parameters, drug content uniformity, in-vitro drug release, drug- excipient interactions (FTIR). IR spectroscopic studies indicated that there are no drug-excipient interactions. The formulations F9 (containing 30mg of HPMC K200M) were found to be promising, which showed maximum drug release within 8 h. These formulations have displayed good bioadhesion strength (4.66 gm respectively).