Vol. 8, Issue 3 (2019)
Dose dependent antidiabetic effect of Mimosa pudica leaves extract in type 2 diabetic rat model
Deepa Rajendiran, Haseena Banu Hedayathullah Khan, Subbulakshmi Packirisamy and Krishnamoorthy Gunasekaran
Diabetes mellitus is a major epidemic health problem characterized by abnormal blood glucose level with alteration of carbohydrate, fat, and protein metabolism. The global prevalence of this disease is increasing day by day and is expected to rise 300 million by 2025. The side effects associated with synthetic drugs has resulted in the shifting of focus towards herbal drugs used in the traditional system of medicine. Mimosa pudica is one such herbal drug that has been used in the Indian system of Medicine against diabetes mellitus. The aim of the present study was to evaluate the effective dose at which the drug exhibits its potential antidiabetic effect. Male Wistar albino rats were divided into seven groups of six animals in each group. Type 2 diabetes was induced in rats by feeding them with high fat diet for two weeks followed by low dose of streptozotocin injection intraperitoneally. The diabetic rats were treated with ethanolic leaf extract of Mimosa pudica with four different doses of 100,200,300 and 400mg/kg/b. wt respectively and were compared with standard drug metformin (200mg/kg/b.wt) for 30 days. Increased level of glucose, glycosylated hemoglobin, lipid profile and reduced level of insulin were observed in diabetic rats. Treatment with Mimosa pudica leaf extract altered the level of glucose, glycosylated hemoglobin, lipid profile and insulin. The extract was found to be effective at the dosage of 300mg/kg/b. wt against high fat diet and streptozotocin induced type 2 diabetes.
How to cite this article:
Deepa Rajendiran, Haseena Banu Hedayathullah Khan, Subbulakshmi Packirisamy and Krishnamoorthy Gunasekaran. . The Pharma Innovation Journal. 2019; 8(3): 01-04.