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Vol. 8, Issue 1 (2019)

Synthesis and screening of 3-(4-Oxo-2-phenyl-1,3-thiazol-5(4h)-ylidene)-1,3-dihydro-2h-indol-2-one - N-methylaniline for in vitro antiinflammatory activity

Author(s):
N Saritha Devi, Divya Sreepada and Sarangapani Manda
Abstract:
A novel synthesis of 3-(4-oxo-2-phenyl-1, 3-thiazol-5(4H)-ylidene)-1, 3-dihydro-2H-indol-2-one - N-methylaniline derivatives is synthesized by cyclization of isatins with thiazolidinones. The synthesized compounds were characterized by spectral data (IR, 1HNMR, MASS) and evaluated for In vitro antiinflammatory activity. The compounds VIi(R=5, 6-dichloro) VIf(R=5-F), VIb(R=5=Cl) and VIh(R=5-Br) are considered to possess more potent antiinflammatory activity when compared to standard drug indomethacin.
Pages: 33-37  |  439 Views  35 Downloads
How to cite this article:
N Saritha Devi, Divya Sreepada and Sarangapani Manda. . The Pharma Innovation Journal. 2019; 8(1): 33-37.
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