Vol. 8, Issue 1 (2019)

Author(s):
N Saritha Devi, Divya Sreepada and Sarangapani Manda

Abstract:
A novel synthesis of 3-(4-oxo-2-phenyl-1, 3-thiazol-5(4H)-ylidene)-1, 3-dihydro-2H-indol-2-one - N-methylaniline derivatives is synthesized by cyclization of isatins with thiazolidinones. The synthesized compounds were characterized by spectral data (IR, ¹HNMR, MASS) and evaluated for In vitro antiinflammatory activity. The compounds VIi(R=5, 6-dichloro) VIf(R=5-F), VIb(R=5=Cl) and VIh(R=5-Br) are considered to possess more potent antiinflammatory activity when compared to standard drug indomethacin.