Vol. 7, Issue 9 (2018)

Author(s):
Guguloth Ramesh, D Madhuri, M Lakshman and Alla Gopal Reddy

Abstract:
Lead and cadmium are most life threatening and well known central nervous system toxicants. This study was carried out to study histopathological changes in pancreas induced by lead and cadmium alone and in combination in rats. Forty eight male albino Wistar rats were divided into 4 groups 12 rats in each group; group 1(control) was given deionized water, group 2 (lead group) was given water with lead acetate @ 30 mg/kg b.wt, group 3 (cadmium group) was given water with cadmium chloride @15 mg/kg b.wt, group 4 (combined group) was given water with both lead acetate@ 30 mg/kg b.wt and cadmium chloride @15 mg/kg b.wt for 28 days. The histopathological changes in pancreas revealed congested vessels, infiltration of mononuclear cells around blood vessels and interlobular ducts, hyperplasia of intra and interlobular ducts, loss of endocrine portion, vacuolar degenerative changes, focal atrophy of islets of Langerhans was notice.