Vol. 7, Issue 9 (2018)

Author(s):
ATM Mostafa Kamal, Md Sohanur Rahman, Kazi Ashfak Ahmed Chowdhury, Mohammad Anisul Islam, Joybrata Mitra, Mridul Kanti Das, Forhad Khan, Mir Mihaj Uddin, Towsif alam and Mohamad Najim Uddin

Abstract:
The study aimed for phytochemical screening and to evaluate the cytotoxic, thrombolytic and anthelmintic activities of methanol extract of the leaves of Glycosmis pentaphylla (Retz.). The cytotoxic activity of crude extract was determined using brine shrimp lethality bioassay and LC₅₀ values of the sample was 11.246 ± 0.65 μg/ml whereas for standard vincristine sulphate it was 8.50 ± 0.16μg/ml, act as a positive control. The extract showed 17.17 ±3.42% clot lytic activity as compared to standard streptokinase’s (30.45% ± 2.67). The anthelmintic activity was done by using Tubifex tubifex with three concentrations viz.,2.5, 5 and 10 mg/ml of the extract was studied which was mainly thoughtful about the finding of time of paralysis and time of death of the worms. The gradual increase in a dose exhibited a gradual increase in the activity. The extract exhibited significant anthelmintic activity at highest concentration of 10 mg/ml as compared with levamisole (1 mg/ml) was performed as standard reference and distilled water as control.