Vol. 7, Issue 8 (2018)

Author(s):
Smita Aher, Ravindranath Saudagar and Mayuri Shinde

Abstract:
The aim research was to prepare fast dissolving tablets of antihypertensive drug Nicardipine Hydrochloride. The solubility of poorly water soluble drug was enhanced by preparing solid dispersion of the drug with β Cyclodextrin in various ratios. The optimized solid dispersion were further kneaded with suitable proportions of superdisintegrant like crosspovidone and ingredients like microcrystalline cellulose, Talc, lactose, sodium saccharine, Magnesium stearate. Fast dissolving tablets of Nicardipine Hydrochloride was prepared by Direct Compression method. The pre-compressive parameters for blend and post-compressive parameters for the prepared tablets were evaluated. FTIR study showed no evidence of drug excipient interaction. DSC and XRD parameters performed on Drug and Solid Dispersion. The optimized formulation was found to be F8 Batch. It was Concluded that fast dissolving tablets of Nicardipine Hydrochloride can be prepared by solid dispersions of drug with β Cyclodextrin and with superdisintegrant provide better dissolution rate within in shorter period of time. Hence effective hypertensive treatment anywhere and anytime particularly for geriatric, pediatric, mentally ill, bedridden and patients who do not have easy access to water.