Vol. 7, Issue 5 (2018)

Author(s):
Ordu JI, Abidde TO and Okafo SE

Abstract:
The binding properties of the gum obtained from fresh leaves of Cochorus olitorious (family (Malvceae) were evaluated, characterized and compared with that of standard gums (sodium CMC and tragacanth). Using the technique of wet granulation method, metronidazole tablets (400 mg unit strength) were prepared with binder concentration of 0%, 2% and 5%w/v respectively. The compressibility properties of the tablet formed were analyzed using density measurement while mechanical properties were analyzed using angle of repose, crushing strength and percentage friability. The tablet release properties were assessed using disintegration and dissolution technique. Tablets produced with C. olitorious gum showed acceptable crushing strength (4.41kgf), disintegration time (2.12minutes) and dissolution rates at low binder concentration of 2%w/v but probable impact of sustained release could be effected if higher concentration of up to 5% w/v was used for the formulation. This result is in comparison to standard binders used for the study.