Vol. 7, Issue 5 (2018)

Author(s):
Khangembam Victoria Chanu, Leishangthem Geeta Devi, Sandeep Kumar Srivastava, Dimpal Thakuria, Meena Kataria and AG Telang

Abstract:
Parkia javanica is a species of the genus Parkia in the family Mimosaceae. Different parts of this plant are edible and also used in traditional practice of medicine. The objective of the study was to analyse the phytochemical constituents of P. javanica seed and evaluation of anticancer activity. Three different extracts, aqueous, ethanolic and methanolic extracts of P. javanica seeds were prepared and phytochemical screenings were carried out. In the extracts, compounds like alkaloids, flavonoids, phenolic compounds, saponins and anthraquinones could be detected by phytochemical analysis, thin layer chromatography and spectrophotometrically through absorption spectra. Based on the results of phytochemical assays, methanolic extract was selected for evaluation of its anticancer activity. The extract produced 50% cell death in HepG2, human liver cancer cells at 0.48 mg/mL with comparatively lesser cytotoxicity to normal cells. The present study showed that P. javanica seed contains bioactive compounds that are known to possess anticancer activity and the methanolic extract caused death in cancer cell at a non-toxic concentration to normal cells