Vol. 7, Issue 5 (2018)

Author(s):
R Saahithya, R Sridhar and P Sriram

Abstract:
The present study was to estimate the lipid peroxidation ad antioxidant profile in male Wistar rats induced with pancreatic atypical acinar cell tumor and its alleviation by Momordica charantia (MC). Ninety six numbers of less than 3 weeks old male albino rats of Wistar strain were randomized into four groups. Rats were administered with a single dose of azaserine at the rate of 30 mg/kg BW intraperitoneally (i.p.) on 21st day of age. Paclitaxel was injected to the azaserine + paclitaxel group (33mg/kg BW) intraperitoneally for 6 weeks after 8 weeks post initiation and aqueous extract of MC (0.34 mL/rat) was administered as oral gavage for 6 weeks after 8 weeks post initiation. Pancreatic tissue samples were collected in sterile normal saline for lipid peroxidation and antioxidant profile from control and treated rats. Momordica charantia protected the pancreas from increased lipid peroxidation, increased antioxidant values compared to azaserine + paclitaxel group.