Vol. 7, Issue 4 (2018)

Author(s):
R Saahithya, R Sridhar, S Hemalatha and P Sriram

Abstract:
The aim of the study was to investigate the hematological changes in Wistar rats induced with pancreatic atypical acinar cell tumor and its alleviation by Momordica charantia (MC). Rats were administered with a single dose of azaserine at the rate of 30 mg/kg BW intraperitoneally (i.p.) on 21st day of age. Paclitaxel was administered to the azaserine + paclitaxel group (33mg/kg BW i.p.) for 6 weeks after 8 weeks post initiation and aqueous extract of MC (0.34mL/rat) was administered as oral gavage for 6 weeks after 8 weeks post initiation. Blood samples were collected at the end of the experiment and processed for hematological studies. There was significant reduction in the level of haemoglobin, packed cell volume, erythrocyte count and neutrophils in the azaserine and azaserine + paclitaxel group. Azaserine + MC did not reveal any significant difference compared to the control group.