Vol. 7, Issue 3 (2018)

Author(s):
HB Kimak and HM Melnychuk

Abstract:
There were examined and treated 37 somatically healthy persons of young age (18-25 years) with generalized periodontitis (GP) of initial-I degree of development, who were included into 2 groups: group І – 20 patients with chronic generalized periodontitis (CGP) and group ІІ – 17 patients with exacerbation of chronic generalized periodontitis (ECGP). Control was provided by 8 practically healthy persons with a healthy oral cavity. For treatment, patients were divided into subgroups: the main (IA – 10 people and ІІА – 9 people) and control ones (IB – 10 people and ІIB – 8 people). The content of interleukin-18 (IL-18) and interleukin-10 (IL-10) in the oral liquid before and after the complex treatment was determined. There was a significant imbalance in the local cellular and humoral immunity, as evidenced by a significant increase of IL-18 and a decrease in the content of IL-10, especially in ECGP. Under the influence of complex therapy, the method developed by us there was a significant regulation of the cytokine spectrum: the level of IL-18 decreased, and IL-10 – increased with the achievement of data in healthy persons. The regulation of immune reactivity with the help of herbal immunomodulators has shown the greater efficiency and prospectivity of the therapeutic complex developed by us, than the use of synthetic medicines used for this purpose, and it has no negative consequences for the health of young people.