Vol. 7, Issue 2 (2018)

Author(s):
U Naseema, Ganne Venkata Sudhakar Rao, N Pazhanivel, V Pandiyan and P Sriram

Abstract:
The present study was designed to investigate the mechanism-based chemo preventive effect of piperine and therapeutic effect of piperine solid lipid nanoparticles against B(a)P induced lung cancer in Swiss albino mice by estimating the status of lipid peroxidation (LPO), enzymatic (Super oxide dismutase (SOD), catalase (CAT), glutathione peroxidise (GPx)) and non-enzymatic antioxidants (Reduced glutathione (GSH), vitamin E, vitamin C) of lung tissues of control and experimental mice. Administration of B(a)P (50mg/kg, p.o) to mice resulted in increased lipid peroxidation with concomitant decrease in the levels of both enzymatic and non-enzymatic antioxidants. Pre-treatment of piperine and post-treatment of piperine solid lipid nanoparticles (100mg/kg, p.o) significantly attenuated all these changes thereby showing potent chemo preventive effect and therapeutic effect respectively.