Vol. 7, Issue 11 (2018)

Author(s):
Akshay Sevak, Jimit Mehta and Rakesh Rawal

Abstract:
All tissues and organs undergo a progressive regenerative decline with aging. Besides changes in local microenvironment the other confounders may be the intrinsic cellular changes or extrinsic exposure to harmful biological or chemical agents with impaired repair mechanism. Therefore, it is important to address the factors which blunt the regenerative potential leading to terminal dysfunction and ways to rejuvenate by retarding aging process through chemoprevention using natural products. The current study was undertaken to assess the regenerative potential of a patented polyherbal formulation “IMMURISE”. Direct human supplementation was done after careful examination of toxicity profile in-vivo in Rat model, Cs137 radionucleotide and heavy metal levels along with microbial load in the formulation and declared safe for human consumption. Regenerative potential was assessed by circulating telomerase activity and DNA damage was estimated by COMET assay. Long term supplementation in healthy and diseased group revealed elevated serum telomerase activity and improvement in DNA damage repair suggestive of rejuvenation through regeneration of local stem cells population in target organ leading to overall wellness and clinical improvement.