Vol. 7, Issue 11 (2018)
Study on prognostic markers in chronic kidney disease patients as an independent risk factors and its management
Kothapalli Rahul Chowdary, Gangavarapu Venkata Mounika, Chalapati Prasanth Chowdary, Rani Samyuktha Velamanakki, Vasudha Bakshi and Mounika Tejaswi Gorle
The relationship of CKD is bidirectionally linked and this association leads to the vicious circle contributing to premature death. There are several risk factors that cause promotion and progression of CKD. The progression of disease and response o the therapeutic interventions in the patients can be predicted by evaluating prognostic markers and traditional risk factors. A few traditional risk factors like age, male gender, older gender, dyslipidemia, smoking, diabetes and the levels of few prognostic markers like haemoglobin, uric acid, serum albumin, Neutrophil-Lymphocyte ratio, para-thyroid hormone can be considered to observe the risk in CKD patients. A total of 131 patients were included in the study. Around 38% of the patients suffered from End-stage renal disease i.e. CKD stage 5. Among Six traditional risk factors considered in the study, majority of patients have hypertension (100%), followed by dyslipidemia (85.5%), and diabetes (82.4%). Higher level of troponin 1 (cardiac biomarker) is seen in 91% of the patients. Considering patients with the end stages of CKD majority of the patients diagnosed with CKD it has have moderate abnormal levels of haemoglobin, severe hyperuricemia, severe albuminuria, severe Neutrophil-Lymphocyte ratio, moderate hypercalcemia, mild hyperphosphataemia, severe levels of parathyroid hormone. In our study, we observed that highly prevalent in the end stages of Chronic Kidney Disease. The prognostic markers included show impact on CKD patients. It seems to be intuitive that early detection and proper management may serve to reduce the risk renal complications.
How to cite this article:
Kothapalli Rahul Chowdary, Gangavarapu Venkata Mounika, Chalapati Prasanth Chowdary, Rani Samyuktha Velamanakki, Vasudha Bakshi and Mounika Tejaswi Gorle. Study on prognostic markers in chronic kidney disease patients as an independent risk factors and its management. The Pharma Innovation Journal. 2018; 7(11): 63-70.