Vol. 7, Issue 1 (2018)

Author(s):
Yuriy Feschenko, Liudmyla Iashyna, Ksenia Nazarenko and Svitlana Opimakh

Abstract:
The most unfavorable variants of combined lung obstructive pathology are small airways obstruction and lung hyperinflation. The aim of this work was to study the factors of the formation of small airways obstruction and lung hyperinflation in patients with combined pathology of asthma and COPD. Severe violations of the lung function parameters in the form of small airways obstruction and pulmonary hyperinflation may exist simultaneously. The common factors of these complications are the elderly age of patients, bronchial obstruction, decreased exercise tolerance, severe dyspnea and high BODE index. The differences in risk factors are the dependence of small bronchial obstruction on the type of local bronchial inflammation and the disease from which the ACO debuted, while lungs hyperinflation depends on the factors of the general low health status and the decrease in the predicted life expectancy of the patients. Among the concomitant cardiovascular pathologies, arterial hypertension and the presence of left ventricular hypertrophy, along with obesity, have a greater effect on the obstruction of the distal respiratory tract, and ischemic heart disease - on lung hyperinflation. Pulmonary hypertension is a factor in the occurrence of both complications.