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Vol. 7, Issue 1 (2018)

Application of beeswax and cetyl alcohol as an excipients in hot-melt coating agents in controlled release metoprolol tartrate plus hydrochlorothiazide capsule formulations

Author(s):
Rahul Wankhade, Dinesh M Sakarkar and Ravindra Pal Singh
Abstract:
The objective of the present study was to design metoprolol tartrate and hydrochlorothiazide controlled release pellets using beeswax and cetyl alcohol as an important hot melt coating (HMC) agents. The pellets were coated by HMC technique using beeswax and cetyl alcohol by using conventional coating pan without the use of spray system. The prepared metoprolol tartrate and hydrochlorothiazide pellets were characterized for drug content, photomicrography, in vitro- dissolution studies, flow properties of pellets. Stability studies were performed for a period of 6 months at 400 ± 2 0C and 75% ± 5% relative humidity. HMC technique is easy rapid and simple method with no agglomeration seen during coating. In – vitro release from pellets at a given level of coating and for present pellets size was dependent upon the physico-chemical properties of the drug. HMC pellets were stable during the course of stability study. Metoprolol tartrate and hydrochlorothiazide pellets using beeswax and cetyl alcohol by HMC technique was employed successfully and capsule formulations were prepared.
Pages: 24-34  |  536 Views  22 Downloads
How to cite this article:
Rahul Wankhade, Dinesh M Sakarkar and Ravindra Pal Singh. Application of beeswax and cetyl alcohol as an excipients in hot-melt coating agents in controlled release metoprolol tartrate plus hydrochlorothiazide capsule formulations. 2018; 7(1): 24-34.
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