Vol. 6, Issue 9 (2017)

Author(s):
SB Bilous

Abstract:
The composition and technology of metronidazole with silver nanoparticles tablets for the treatment of infectious diseases has been developed. The choice of auxiliary substances for the development of tablets is justified by the mathematical planning of the experiment. For the selection of the optimal composition of the tablets a study of the uniformity of mass of tablets, resistance to crushing, friability of uncoated tablets, disintegration of tablets and evaluation of their appearance was conducted. The dispersion analysis of the obtained results made it possible to choose the optimal composition of auxiliary substances for tablets: magnesium carbonate heavy, microcrystalline cellulose 102, sodium starch glycollate and magnesium stearate.