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Journal code(s)
- E-ISSN Number: 2277-7695
- P-ISSN Number: 2349-8242
- CODEN Code: PIHNBQ
- ZDB-Number: 2663038-2
- IC Journal ID: 7725
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Vol. 6, Issue 9 (2017)
Insilico molecular docking analysis of isolated compounds of Ocimum sanctum against two related targets to diabetes
Author(s):
Abhijit Pathak, Sumaiya Nahid, Abu Sayed Manik, Mohammed Shahariar Rahman, Fowjia Taher Rumpa, Mohuya Majumder and Arkajyoti Paul
Abhijit Pathak, Sumaiya Nahid, Abu Sayed Manik, Mohammed Shahariar Rahman, Fowjia Taher Rumpa, Mohuya Majumder and Arkajyoti Paul
Abstract:
Background: To investigation antidiabetic activity of the isolated compounds of Ocimum sanctum against two responsible proteins α-amylase enzyme and Glucokinase).
Background: To investigation antidiabetic activity of the isolated compounds of Ocimum sanctum against two responsible proteins α-amylase enzyme and Glucokinase).
Methodology: For this purpose we subjected the active compounds of Ocimum sanctum of to reveal its potentiality by molecular docking analysis to find out its potent compound against Diabetics which was done by Maestro v 10.1 (Schrodinger) docking analysis.
Results: A wide range of docking score found during molecular docking by Maestro v 10.1 (Schrodinger). Among of the compounds Carvacrol had the lowest docking score against α-amylase enzyme and Glucokinase which is -5.581 kj/mol and -7.322 kj/mol respectively.
Conclusion: Carvacrol from Ocimum sanctum detected with significant docking score which may be a potent antidiabetics compound because the less the docking score will be, the compound will be more potent.
Pages: 148-151 | 1449 Views 126 Downloads
How to cite this article:
Abhijit Pathak, Sumaiya Nahid, Abu Sayed Manik, Mohammed Shahariar Rahman, Fowjia Taher Rumpa, Mohuya Majumder, Arkajyoti Paul. Insilico molecular docking analysis of isolated compounds of Ocimum sanctum against two related targets to diabetes. Pharma Innovation 2017;6(9):148-151.
Journal code(s)
- E-ISSN Number: 2277-7695
- P-ISSN Number: 2349-8242
- CODEN Code: PIHNBQ
- ZDB-Number: 2663038-2
- IC Journal ID: 7725
Main Menu
Special Issue
Copyright Form
Identifier
The Pharma Innovation Journal
