To evaluate the antiulcer effect of Sodium Cromoglycate in comparision with Ranitidine in Ethanol induced and NSAID induced ulcer in rats.
Background: Peptic ulcer disease is a break in the lining of the stomach, first part of the small intestine, or occasionally the lower esophagus. An ulcer in the stomach is known as a gastric ulcer while that in the first part of the intestines is known as duodenal ulcer . There are many anti-ulcer agents like H2-receptor antagonists, Proton pump inhibitors to alleviate the symptoms of peptic ulcer disease. Though these medications considered to be safe, some of the recent studies have shown that role of Proton pump inhibitors in aggravating myocardial infarction and other cardiac ailments. Therefore search for a new potent, safe and nontoxic drug continues.
Materials and Methods: This animal study was a cross sectional, observational in nature carried out in male Wistar rats. Animals were divided into four groups with six animals in each group. GROUP 1: Standard drug Ranitidine in Aspirin induced ulcer. GROUP 2: Test drug Sodium Cromoglycate in Aspirin induced ulcer. GROUP 3: Ranitidine in Ethanol induced ulcer. GROUP 4: Sodium Cromoglycate in Ethanol induced ulcer. Parameters like number of ulcers, severity of ulcers and Ulcer Index was calculated.
Results: In the present study, Mean number of ulcers with Group I is 3.16 + 3.44, in Group II is 4.83 + 2.32, (p<0.05). In Group III is 2.33 + 2.72 and in Group IV is 3.83 + 2.32, (p<0.05) is statistically significant. Mean Grade of Severity of ulcers in Group I is 1.13 + 1.12, in Group II is 1.72 + 0.12, (p<0.05). In Group III is 1.01 + 1.06 and in Group IV is 1.50 + 0.18, (p<0.05). Is statistically significant. Ulcer index in Group I – 12.62, Group II – 16.55, Group III –11.67 and in Group IV-15.33.
Conclusion: Sodium Cromoglycate is an effective agent in ulcer healing, in Ethanol induced and NSAID induced ulcers in rats but is less compared to that of Standard drug Ranitidine.