Vol. 6, Issue 5 (2017)

Author(s):
Amit Kumar Roy, Md Mamun Ahmed, Md Mahedi Hasan Nahid, Kaniz Afroz Tanni and Mohammad Shahriar

Abstract:
Etoricoxib is a highly selective cyclooxygenage-2 (COX-2) inhibitor administered orally as an analgesic drug that has shown some improved efficacy versus traditional NSAIDs. The study was intended to evaluate different physicochemical parameters of generic etoricoxib tablet from different manufacturers using in vitro tests. The tested brand products had satisfactory hardness, average weight, friability, disintegration and potency. All the brands released more than 80% drug in the first 45 minutes except for brand E9. The dissolution profiles were compared with the use of difference factor (f1) and similarity factor (f2), showing that all the brands except E9 are similar with brand E1 and can be used interchangeably.