Twenty-eight patients were examined, aged from 20 to 44 years with no somatic pathology, including 8 persons with healthy periodontium and 20 patients with the chronic generalized periodontitis, where half of the people were diagnosed with the initial-I stage, while the rest had the I-II stage of the disease development. Content of the cytokines in oral fluid was estimated using the method of enzyme-linked immunosorbent assay before and after the treatment. Level of the proinflammatory cytokines IL-1β and IL-6 increased significantly in patients with the GP, while apparently the content of anti-inflammatory cytokine IL-10 decreased in oral fluid, especially in case of the GP at the I-II stage of development.
Complex treatment included professional hygiene, local and general medical treatment with natural origin medicines, as well as photodynamic therapy. As a result of combined therapy, patients with GP achieved significant normalization of level of the studied cytokines in oral fluid, especially in case of the GP at the initial-I stage: decreased IL-1β and IL-6 and increased IL-10 (with achieving health indicator), which is illustrative of the regulation of cytokine imbalance in local immune defense of oral cavity. The data received give us an opportunity to recommend the method we have developed for the GP treatment highly.