Vol. 6, Issue 3 (2017)

Author(s):
Parhate SM, Ashtaputre MD, Harwani RS and Inamdar Khalid

Abstract:
Patients suffering from renal edema, hepatic edema, hypertension and ischaemic heart diseases receiving diuretics, were enrolled to study the type of serum electrolyte imbalance and the time lag between diuretics administration and the appearance of adverse effects. The adverse effects (6.8%) were hypokalaemia (2.9%), followed by hyponatraemia (2.4%) and hyperkalaemia (1.5%). The earliest adverse effects found at 2 month interval were hyponatraemia (22%), hypokalaemia (13%), and hyperkalaemia (3.2%). At 4-10 months interval similar ADE were detected with variable pattern. Delayed effects namely hypokalaemia (furosemide-6.4%), hyperkalaemia (spiranolactone-3.2%) were evident at as late as 12 months interval. None of the angina pectoris group showed adverse effects. Maximum patients belong to higher age 61-75 yrs; (37.5%) and most were patients of renal edema (38.7%).