Vol. 6, Issue 3 (2017)

Author(s):
Idrissa Doumbia, Karamoko Ouattara, Coulibaly Founzegue Amadou, Houphouet Felix Yapi, Allico Joseph Djaman and Jean David N'guessan

Abstract:
We investigated the ionic disturbs of Mareya micrantha (Euphorbiaceae) in rabbits. It is a plant traditionally used against dermatoid affections and for its laxative, abortive and oxytocic properties in Côte d'Ivoire and elsewhere in West Africa. For this study, different batches of rabbits were injected with increasing doses of aqueous extract of Mareya micrantha (MAR). Then changes in serum calcium, magnesium, chloride, sodium and potassium were evaluated. This study showed that the use of the aqueous extract of Mareya micrantha with doses between 12.5 and 200 mg / kg body weight (bw) in rabbits causes a significant variation (P <0.05) of calcium serum concentrations. But there is no significant change (P> 0.05) of magnesium, chloride, sodium and potassium serum concentration. Finally, this study suggests that a reduction of the dose (100 mg / kg) and time of treatment (4 weeks) may help to avoid ionic disturbs other time. This dose of 100 mg /kg/bw which is much higher than the therapeutic dose, confer on Mareya micrantha a safety margin 200 (Tolerate Maximum Dose/ Therapeutic dose) very interesting.