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Journal code(s)
- E-ISSN Number: 2277-7695
- P-ISSN Number: 2349-8242
- CODEN Code: PIHNBQ
- ZDB-Number: 2663038-2
- IC Journal ID: 7725
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Vol. 6, Issue 2 (2017)
Floating controlled drug delivery system of verapamil loaded Microballoons
Author(s):
Saniya Jawed, Amit Sorathiya and AK Srivastava
Saniya Jawed, Amit Sorathiya and AK Srivastava
Abstract:
The purpose of this study was to develop a sustained release floating drug delivery system (hollow microsphere or microballoons) of Verapamil hydrochloride using Ethyl cellulose and Eudragit RL 100. Microballoons were prepared by non – aqueous solvent evaporation method and optimized by changing drug: polymer ratio, and polymer combination. Thirteen batches containing only Ethyl Cellulose, only Eudragit RL 100 and both Ethyl Cellulose and Eudragit RL 100 were prepared and evaluated. Drug to Polymer ratio of 1:2 was found to be optimized.
The purpose of this study was to develop a sustained release floating drug delivery system (hollow microsphere or microballoons) of Verapamil hydrochloride using Ethyl cellulose and Eudragit RL 100. Microballoons were prepared by non – aqueous solvent evaporation method and optimized by changing drug: polymer ratio, and polymer combination. Thirteen batches containing only Ethyl Cellulose, only Eudragit RL 100 and both Ethyl Cellulose and Eudragit RL 100 were prepared and evaluated. Drug to Polymer ratio of 1:2 was found to be optimized.
Microballoons were stable, white colored, spherical, free flowing in nature and showed controlled release up to 12 hours. The drug release from the microballoons followed Higuchi model indicating diffusion controlled non-Fickian drug release. Optimized formulation batch showed percentage yield 80.99%, percentage buoyancy 84.05±0.93%, particle size 301.17±3.43µm and percentage drug entrapment efficiency 81.45 ± 0.21%.
Pages: 85-88 | 1603 Views 137 Downloads
How to cite this article:
Saniya Jawed, Amit Sorathiya, AK Srivastava. Floating controlled drug delivery system of verapamil loaded Microballoons. Pharma Innovation 2017;6(2):85-88.
Journal code(s)
- E-ISSN Number: 2277-7695
- P-ISSN Number: 2349-8242
- CODEN Code: PIHNBQ
- ZDB-Number: 2663038-2
- IC Journal ID: 7725
Main Menu
Special Issue
Copyright Form
Identifier
The Pharma Innovation Journal
