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Vol. 6, Issue 2 (2017)

A paradigm of lipoxygenase and cyclooxygenase metabolism: Focusing new insights and positive biofeedback in the treatment and chemoprevention of pancreatic cancer

Author(s):
Partha Majumder
Abstract:
In human body, we have two essential fatty acids such as linoleic acid and arachidonic acid which are playing an important role in the development and progression of pancreatic cancer. Both of these fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Extensive scientific studies show that abnormal expression and activities of both cyclooxygenases and lipoxygenases are correlated with pancreatic cancer. In this review, my aim is to focus a brief summary regarding (1) our understanding of the roles of these enzymes as causal factors of pancreatic cancer tumorigenesis and progression; and (2) positive biofeedback of using cyclooxygenase and lipoxygenase inhibitors for the treatment and prevention of pancreatic cancer.
Pages: 22-30  |  595 Views  18 Downloads
How to cite this article:
Partha Majumder. A paradigm of lipoxygenase and cyclooxygenase metabolism: Focusing new insights and positive biofeedback in the treatment and chemoprevention of pancreatic cancer. 2017; 6(2): 22-30.
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