Vol. 6, Issue 11 (2017)

Author(s):
Yuriy Ivanovich Feschenko, Liudmyla Aleksandrovna Iashyna, Ksenia Vladimirovna Nazarenko and Svetlana Genrichovna Opimakh

Abstract:
For a combined pathology of asthma and chronic obstructive pulmonary disease (asthma-COPD overlap - ACO), a higher frequency of exacerbations and their severe course, accelerated pulmonary function decline, a decrease in the quality of life of patients, a high incidence of comorbid diseases, and other negative effects are characteristic. The aim of this work was to study the risk factors of an unfavorable prognosis for the duration of life in patients with asthma-COPD overlap. Risk factors that reduce the life expectancy of patients with ACO are the elderly age, the onset of COPD, the more severe clinical course (mMRC, CAT and BODE scales), decreased physical endurance, severe bronchial obstruction, pulmonary hyperinflation, systemic and eosinophilic inflammation, and the most important factors of low survival are concomitant cardiovascular disease and diabetes mellitus. The practical value of the data obtained is the widespread use of available disease assessment tools (mMRC, CAT and BODE), the appointment of adequate bronchodilator and anti-inflammatory therapy for ACO, and the mandatory detection and treatment of concomitant diseases.