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Vol. 6, Issue 11 (2017)

Evaluation of antidiabetic activity of ethanolic extract of Ocimum sanctum Linn. leaves in alloxan induced diabetic albino rats

Ahmed SK, Sunil M, Dr. Chakrapani Cheekavolu, Sampath D and Sharanya M
Background: The study of plants having Antidiabetic activity may give a new approach in the treatment of diabetes mellitus. The present research study was aimed to evaluate Antidiabetic effect of ethanolic extract on leaves of Ocimum sanctum Linn. (EEOS) in alloxan induced diabetic albino rats.
Material and Method: Albino rats weighing 150- 250 grams were grouped into five(5) equal groups taking six animals in each group (n=6). Group I served as control (normal control), whereas Group II was served as diabetic control, where as Group III and IV received ethanolic extract of leaves of Ocimum sanctum Linn. (EEOS) at a doses of 250 mg/kg and 500 mg/kg orally respectively, Group V was given standard drug (Glibenclamide 5mg/kg) for 28 consecutive days and the antidiabetic effect of the Ocimum sanctum Linn. leaves ethanolic extract on blood serum glucose levels was measured at regular intervals. At the end of the study blood samples were collected from all the animals for biochemical estimation.
Result: The present study clearly indicate that the test drug compound EEOS has statistically significant (p ≤0.05) and sustained oral hypoglycaemic activity which is comparable with the hypoglycaemic effect of the standard drug Glibenclamide.
Conclusion: The present research study confirms that EEOS has antidiabetic activity against alloxan induced diabetic albino rats. It could be a novel antidiabetic agent and also a dietary adjunct for the management of type 2 diabetes and its complication. Further studies are required to confirm the antidiabetic activity of individual phytochemical constituents of Ocimum sanctum.
Pages: 115-119  |  695 Views  24 Downloads
How to cite this article:
Ahmed SK, Sunil M, Dr. Chakrapani Cheekavolu, Sampath D and Sharanya M. . The Pharma Innovation Journal. 2017; 6(11): 115-119.
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