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Vol. 6, Issue 11 (2017)

Synthetic steroids containing a tertiary butyl group and their biological activities

Author(s):
Tatyana A Gloriozova, Vladimir V Poroikov and Valery M Dembitsky
Abstract:
The present review article describes biological activities of synthetic steroids containing a tertiary butyl group. More than 25 biological active steroids have shown confirmed antitumor, antiviral, or apoptosis, and other activities. The structures, reported and predicted activities of a selection of describes steroids are reported. With the computer program PASS based on structure–activity relationships (SAR) some additional activities are also predicted, which point toward new possible applications of these lipids. This article emphasizes the role of steroids containing a tertiary butyl group as an important source of leads for drug discovery.
Pages: 84-92  |  318 Views  8 Downloads
How to cite this article:
Tatyana A Gloriozova, Vladimir V Poroikov and Valery M Dembitsky. Synthetic steroids containing a tertiary butyl group and their biological activities. 2017; 6(11): 84-92.
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