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Vol. 6, Issue 1 (2017)

Design and optimization of In-situ floating gel containing ondansetron hydrochloride dihydrate using 32 factorial design

Shelke Gajanan, Dhobale Shankar, Jadhav Suresh and Gaikwad Dushyant
The aim of the present study was to develop an in-situ floating gel of Ondansetron HCl dihydrate. The Ondansetron HCl dihydrate has low gastro intestinal Transit time that result in low absorption of drug. Floating in-situ gel is most suitable form to achieve greater absorption of drug. In-situ gel floats on the gastric fluid for sufficient time and also increases the gastric transit time. An in-situ floating gel prepared by using various excipients like sodium alginate, calcium carbonate, sodium citrate, D-mannitol, methyl paraben, propyl paraben. The compatibility study was performed by using FT-IR. Formulations were optimized by using 32-factorial designs. Concentration of Sodium Alginate and calcium carbonate were selected as independent variables whereas floating lag time and drug release after 8 hrs (Q8) were selected as dependent variables. The prepared formulations were evaluated for viscosity, floating lag time, duration of floating, in- vitro gelation and in-vitro drug release. All formulations showed floating within 60 s and had total floating time 24 hrs.
The concentration of Sodium Alginate and calcium carbonate had significant influence on floating lag time, cumulative percentage drug release in 8 hrs. Among different formulae tested, formulation A5 showed optimum floating lag time (38sec) and drug release after 8 hrs (98.56%). Therefore, floating in- situ gelling of Ondansetron HCl dihydrate containing Sodium Alginate as a gelling polymer to sustain the drug release for 8 hrs. All the formulations showed good pourability.
Pages: 83-88  |  777 Views  19 Downloads
How to cite this article:
Shelke Gajanan, Dhobale Shankar, Jadhav Suresh and Gaikwad Dushyant. . The Pharma Innovation Journal. 2017; 6(1): 83-88.
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