The aim of the present study was to develop an in-situ
floating gel of Ondansetron HCl dihydrate. The Ondansetron HCl dihydrate has low gastro intestinal Transit time that result in low absorption of drug. Floating in-situ
gel is most suitable form to achieve greater absorption of drug. In-situ
gel floats on the gastric fluid for sufficient time and also increases the gastric transit time. An in-situ
floating gel prepared by using various excipients like sodium alginate, calcium carbonate, sodium citrate, D-mannitol, methyl paraben, propyl paraben. The compatibility study was performed by using FT-IR. Formulations were optimized by using 32
-factorial designs. Concentration of Sodium Alginate and calcium carbonate were selected as independent variables whereas floating lag time and drug release after 8 hrs (Q8
) were selected as dependent variables. The prepared formulations were evaluated for viscosity, floating lag time, duration of floating, in- vitro
gelation and in-vitro
drug release. All formulations showed floating within 60 s and had total floating time 24 hrs.
The concentration of Sodium Alginate and calcium carbonate had significant influence on floating lag time, cumulative percentage drug release in 8 hrs. Among different formulae tested, formulation A5 showed optimum floating lag time (38sec) and drug release after 8 hrs (98.56%). Therefore, floating in- situ gelling of Ondansetron HCl dihydrate containing Sodium Alginate as a gelling polymer to sustain the drug release for 8 hrs. All the formulations showed good pourability.