Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 5, Issue 8 (2016)

An optimization study of rifampicin oral suspension formulation using central composite design of experiment model

Author(s):
SA Kale and VH Bajaj
Abstract:
In the present study, an optimization design of experiments was applied in evaluation of oral suspension formulation of Rifampicin. Rifampicin is a widely used antibiotic to treat a several types of bacterial infections like tuberculosis, leprosy, and Legionnaire's disease. Central Composite Design optimization design was used to study main and interaction effect of variables affecting CQAs. Impact of formulation and manufacturing process variables like hydrocolloid (%) and homogenization speed (rpm) was studied on critical quality attributes (CQAs) of Rifampicin oral suspension. Viscosity (cps) and content uniformity (% C.V.) were identified as CQAs of Rifampicin oral suspension.
Pages: 11-17  |  725 Views  24 Downloads
How to cite this article:
SA Kale and VH Bajaj. An optimization study of rifampicin oral suspension formulation using central composite design of experiment model. 2016; 5(8): 11-17.
Journals List Click Here Research Journals Research Journals
Call for book chapter