Vol. 5, Issue 7 (2016)

Author(s):
Sunena, Dinanath Mishra, Shailendra Kumar Singh, Anil Kumar

Abstract:
The present study aimed to formulate thiolated chitosan nanoparticles of zolmitriptan for brain targeting via intranasal drug delivery. The thiolated chitosan was synthesized by reaction of thiogycolic acid and chitosan in presence of catalyst and characterized using FTIR and DSC thermogram. Drug loaded nanoparticles were prepared by ionic gelation of thiolated chitosan by using sodium tripolyphosphate. The prepared nanoparticles were characterized by FTIR spectroscopy to confirm the drug loading without any chemical interactions between the drug and excipients. The morphology and size of the nanoparticles was affirmed using TEM analysis. The drug permeation of nanoparticles through nasal mucosa was evaluated by Franz diffusion cell for intranasal drug delivery