Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 5, Issue 7 (2016)

Development and characterization of zolmitriptan thiolated chitosan nanoparticles for intranasal drug delivery

Author(s):
Sunena, Dinanath Mishra, Shailendra Kumar Singh, Anil Kumar
Abstract:
The present study aimed to formulate thiolated chitosan nanoparticles of zolmitriptan for brain targeting via intranasal drug delivery. The thiolated chitosan was synthesized by reaction of thiogycolic acid and chitosan in presence of catalyst and characterized using FTIR and DSC thermogram. Drug loaded nanoparticles were prepared by ionic gelation of thiolated chitosan by using sodium tripolyphosphate. The prepared nanoparticles were characterized by FTIR spectroscopy to confirm the drug loading without any chemical interactions between the drug and excipients. The morphology and size of the nanoparticles was affirmed using TEM analysis. The drug permeation of nanoparticles through nasal mucosa was evaluated by Franz diffusion cell for intranasal drug delivery
Pages: 19-23  |  690 Views  37 Downloads
How to cite this article:
Sunena, Dinanath Mishra, Shailendra Kumar Singh, Anil Kumar. Development and characterization of zolmitriptan thiolated chitosan nanoparticles for intranasal drug delivery. 2016; 5(7): 19-23.
Journals List Click Here Research Journals Research Journals
Call for book chapter