Vol. 5, Issue 6 (2016)
A prospective study comparing nitrofurantoin vs fluoroquinolones in the therapy of uncomplicated urinary tract infection
Dr. Mathew George, Dr. Lincy Joseph, Mrs. Leena PN and Ann Mary Kurian
Urinary Tract Infection is one of the most common diseases encountered in humans today, especially in women and children. E. coli has consistently been reported to be the major cause of this disease. Nitrofurantoin, Fluoroquinolones and Trimethoprim-Sulfamethoxazole are the most commonly used classes of drugs for the therapy of Urinary tract infection. However uropathogens have become greatly resistant to these drugs. The aim of this study was to assess the comparative effectiveness between Nitrofurantoin and Fluoroquinolones, to determine the resistance to drugs reported as well as to analyze the change in Quality of Life trends upon contacting urinary tract infection. Overall, Nitrofurantoin appears to be the best option to manage UTI, in light of the increasing reports of Fluoroquinolone resistance. E. coli continues to be the major pathogen responsible which increases the chances of resistance development. The Quality of life was found to decrease in all subclasses when the participants developed the infection. This disease is not to be taken lightly as the associated decrease in quality of life is significant. Thus, it is the need of the hour to use the most rational antibiotic therapy to manage UTI.
How to cite this article:
Dr. Mathew George, Dr. Lincy Joseph, Mrs. Leena PN and Ann Mary Kurian. A prospective study comparing nitrofurantoin vs fluoroquinolones in the therapy of uncomplicated urinary tract infection. The Pharma Innovation Journal. 2016; 5(6): 47-52.