Vol. 5, Issue 4 (2016)

Author(s):
Oleksandr Rodynskiy, Igor Gutnik, Volodymyr Kramarchuk

Abstract:
Background: special attention has been paid to compression neuropathy disclosure mechanisms in the early stages of its development and impact on the process of biologically active substances such as hormones. The ability of sex hormones affect the rate of protein metabolism and, consequently and causes changes in the electrical activity of neurons in the central nervous system caused so that it is necessary to study the impact of testosterone of on the development of post denervation hyperreflexia. Methods: the aim of present study was to explore features of bioelectrical activity of interneurons pools of the spinal cord on early experimental compression neuropathy and testosterone effects. Results: in conditions of experimental compression neuropathy against the background of testosterone introduction observed changes in the activity of neurons posterior horns of spinal cord, shown to reduce the occurrence threshold of potential of dorsal surface of spinal cord. Changes of chronaxie of dorsal surface potential significant about changes of biophysical characteristics of Na⁺-channels, and require more detailed study. Conclusions: metabolic transformation in conditions of compression neuropathy against the background of the introduction of testosterone leads to decrease threshold and fails to operate afferent conductors interneurons pools of spinal cord.