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Vol. 5, Issue 3 (2016)

Heat-shock protein 70-2 gene (1267A→G) in association with vulvovaginitis and cytokines levels in juvenile girls of Northern Bukovina

Author(s):
Larysa Sydorchuk, Oksana Bochkariova, Oksana Andriyets, Andriy Sydorchuk, Oksana Bodnariuk
Abstract:
The aim of the study was to analyze the cytokines levels depending on 1267А⟶G polymorphism of HSP70-2 gene in 70 juvenile age girls of Northern Bukovina (Western Ukraine) with vulvovaginitis. The homozygous mutation of HSP70-2 gene (rs1061581) in study group was found in 2.86% cases, and was absent in control. Wild G allele of HSP70-2 gene present in every second teenager. The vulvovaginitis course in juvenile girls is accompanied by an increase of cellular immunity activity with prevailing of high and moderate production of pro-inflammatory cytokines (IL-1β and TNFα) 2.89 times (𝒳2=33.03, р<0.001) (especially in the GG-genotype carriers by 12.13% (р=0.04) and 7.19 (р=0.055), respectively) with compensatory increase of humoral immunity activity by synthesis of anti-inflammatory IL-10 by 22.01% (р<0.001) and activation of local immunity of the vaginal mucosa by the secretory sIgA increase 2.6 times (р<0.001), which did not depend on allele condition of HSP70-2 gene. Genotypes and alleles of HSP70-2 gene (rs1061581) are not the additional risk factors of the vulvovaginitis in juvenile girls of Northern Bukovina.
Pages: 19-23  |  783 Views  24 Downloads
How to cite this article:
Larysa Sydorchuk, Oksana Bochkariova, Oksana Andriyets, Andriy Sydorchuk, Oksana Bodnariuk. Heat-shock protein 70-2 gene (1267A→G) in association with vulvovaginitis and cytokines levels in juvenile girls of Northern Bukovina. 2016; 5(3): 19-23.
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