Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 5, Issue 2 (2016)

"Solid as solvent"- Novel spectrophotometric analysis of Satranidazole tablets using solids (Eutectic Mixture of Phenol and Metformin Hydrochloride) as solubilizing agents (Mixed Solvency Concept)

Author(s):
RK Maheshwari, Ritu Sharma
Abstract:
The pollution and toxicity caused by most of the organic solvents is a big challenge. Using mixed solvency concept, innumerable solvent systems can be developed based on an assumption that each substance possesses solubilizing power which can be further explored to develop eco-friendly methods in the area of drug estimation and formulation precluding the use of any toxic organic solvents. In present study we used eutectic mixture of phenol and metformin hydrochloride (PMHCl 41) which is obtained by vigorous trituration of crystals of phenol and metformin hydrochloride (in 4:1 ratio) employed to extract (dissolve) Satranidazole from fine tablet triturate powder. Distilled water is used for dilution to carry out spectrophotometric analysis at 320nm without using any types of organic solvents. The solubility of Satranidazole in distilled water at room temperature was found to be 6.41mg/ml while the solubility of Satranidazole in PMHCl 41 was more than 150mg/ml (of PMHCl 41). The accuracy, reproducibility and precision of the method were confirmed by continuous recovery studies and statistical data. The presence of excipients, eutectic mixture PMHCl 41 did not interfere in spectrophotometric analysis at 320nm. Phenol and metformin hydrochloride PMHCL 41 does not interfere above 300nm.
Pages: 42-43  |  774 Views  19 Downloads
How to cite this article:
RK Maheshwari, Ritu Sharma. "Solid as solvent"- Novel spectrophotometric analysis of Satranidazole tablets using solids (Eutectic Mixture of Phenol and Metformin Hydrochloride) as solubilizing agents (Mixed Solvency Concept). The Pharma Innovation Journal. 2016; 5(2): 42-43.
Journals List Click Here Research Journals Research Journals
Call for book chapter