Vol. 5, Issue 11 (2016)
Morphological Changes in Mucous Membrane of Bronchi After 180-day roflumilast treatment in subjects with severe COPD
Mykola Ostrovskyy, Iryna Savelikhina, Oleksandr Varunkiv, Nataliia Ivanyshyn, Mariana Kulynych-Miskiv, Galyna Korzh and Kseniia Ostrovska
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by a decline in lung function over time and accompanied by respiratory symptoms, primarily dyspnea, cough, fatigue, and sputum production. Consequently, COPD is associated with a significant economic burden, including frequent hospitalization and disability. By 2020 COPD is predicted to be the third-leading cause of death worldwide (from sixth in 1990) and fifth leading cause of years lost through early mortality (12th in 1990). For 9 people with severe COPD before treatment and after 180 days treatment with roflumilast were performed biopsies of the mucous membrane of the bronchi. Verification of the diagnosis and its formulation confirmed with the orders of Ministry of Health of Ukraine № 128 from 19.03.2007. "On approval of clinical protocols of medical care in the specialty pulmonology"  and the Order of Ministry of Health of Ukraine № 555 of June, 27, 2013 .
How to cite this article:
Mykola Ostrovskyy, Iryna Savelikhina, Oleksandr Varunkiv, Nataliia Ivanyshyn, Mariana Kulynych-Miskiv, Galyna Korzh and Kseniia Ostrovska. . The Pharma Innovation Journal. 2016; 5(11): 10-13.