Vol. 5, Issue 10 (2016)

Author(s):
Arya Mohan K, Shan P Mohammed and P Sri Ganesan

Abstract:
Hyperlipidemia and oxidative stress are major risk factors for atherosclerosis, and all three are among the most important risk factors for cardiovascular diseases and conditions. Averrhoa bilimbi is a traditional Medicine used as a local remedy for various ailments like hypertension, Diabetes mellitus and dyslipidemia. When used in high concentrations the fruit juice can lead to Acute renal failure due to acute tubular necrosis, owing to its high oxalate contents which results in intratubular oxalate crystal deposition therefore we are focussing on the flower of Averrhoa bilimbi Hyperlipidaemia was induced by a single intra-peritoneal injection of Triton X-100 at a dose of 100 mg/kg. body weight. Group 1 was kept as Normal, i.e. no administration of drug and extract follows normal diet. Group 2 was kept as toxic control i.e, no administration of drugs after the introduction of hyperlipidemia. The regression group i.e. the animals of Groups C, D, E, fourty eight hours after inducing Hyperlipidaemia different doses of drug was administered for seven days. For Group C Standard drug- Atorvastatin and for Groups D,E different doses of study drug was given i.e, methanolic extract of Averrhoa bilimbi 200mg/kg and 400mg/kg. The results obtained from the present study indicated that Averrhoa bilimbi, has potential antioxidant and hypolipidemic activity and it may be the due to the synergistic effect of the major phyto-constituents like flavonoids, tannins, terpinoids and phenols that are highly present in the extract. But further studies are required to provide the exact mechanism of action of the reported activities by using purified fraction of the same.