Vol. 5, Issue 1 (2016)

Author(s):
Luybov Dron,Iryna Kupnovytska

Abstract:
The article deals with the problem of peripheral hemodynamics correction in the systemic and pulmonary circulation, circadian profiles of blood pressure and respiratory ventilation in patients with stage 2 hypertension, burdened by obstructive pulmonary disease, with the use of L-arginine – exogenous source of nitric oxide. Material and methods of investigation: This study investigated 100 patients with stage 2 hypertension (2nd- and 3rd-degree) including 80 patients with hypertension, burdened by stage 2 pulmonary hypertension of bronchopulmonary origin, and 20 patients with essential hypertension of the identical stage and degree at the age of 56.5±4.12. Results: It has been observed that chronic obstructive disease burdens the course of hypertension by peripheral hemodynamics deterioration and systolic pressure increase in the pulmonary circulation leading to heart remodeling. A number of positive effects of L-arginine on the course of the cardiovascular and respiratory systems comorbide pathology have been established. Conclusions: L-arginine, used in combination therapy in patients with hypertension accompanied by chronic obstructive disease, induces antihypertensive therapy potentiation, bronchial patency improvement, and circadian profiles of blood pressure resetting.